高灵敏度化学发光底物|SuperSignal MaxiSignal Maximum Sensitivity Substrate（36224ES）

[ 1 ]Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

[ 2 ]The Small Molecule H89 Facilitates Mesenchymal Stem Cell-derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration

[ 3 ]Decoding IGLL5 Mutation-Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

[ 4 ]Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

[ 5 ]Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

[ 6 ]Triple-modal PPy/ZIF-8 nanoparticles amplify autophagy and block autophagic flux via photothermal-ROS-zinc ion synergy for cancer therapy

[ 7 ]Bimetallic MOF-engineered 3D-printed PEEK implants orchestrate osteoregeneration via macrophage reprogramming

[ 8 ]The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity

[ 9 ]Macrophage Phenotype–Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles

[ 10 ]p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer

[ 11 ]Bergenin, a bioactive compound from Bergenia purpurascens, ameliorates psoriasis by targeting γδT17 cells via PPARγ-mediated PROX1 ubiquitination and degradation

[ 12 ]Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via promoting bile acid reabsorption and decreasing focal adhesion kinase signaling revealed by metabolomics and proteomics

[ 13 ]A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity

[ 14 ]Chronic stress drives gastric cancer lymph node metastasis via NETosis through a feedforward ACh-NGF axis-mediated PKC-γ/STAT3 pathway

[ 15 ]miR-329-3p derived from mast cells-exosomes exacerbates intestinal ischemia-reperfusion injury by targeting ATG10 to regulate autophagy

[ 16 ]Nelumbo nucifera extract alleviates UVB-induced hyperpigmentation via NOX4-mediated AMPK-YAP-ATG5 signaling pathway

[ 17 ]Anti-Tumor Effects of Guggulsterone in Osteosarcoma: Role of SIRT3-Mediated PINK1-Parkin Mitophagy Activation

[ 18 ]Tubeimoside Ⅰ Targets Sodium/Potassium ATPase alpha 1 Subunit to Selectively Eliminate Senescent Cells and Alleviate Aging-associated Abnormalities

[ 19 ]TSLP-driven B cell hyper-activation impairs intestinal epithelial homeostasis predisposing to enterocolitis in Hirschsprung disease

[ 20 ]SPAG5 promotes ferroptosis and enhances chemotherapy efficacy in locally advanced colorectal cancer via upregulating intracellular ROS levels

[ 21 ]Excitatory neurons and astrocytes-specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single-cell spatial transcriptomics

[ 22 ]Single-cell transcriptomic landscape of the mid-secretory eutopic endometrium reveals receptivity defects in adenomyosis

[ 23 ]MTHFD2 is required for DNA repair and implicated in LUAD radiotherapy resistance

[ 24 ]Hypoxia-induced XBP1s-MYDGF axis suppresses ferroptosis through UBQLN1-mediated stabilization of LCN2 in gastric cancer

[ 25 ]Conformationally Tuned Cyclic RGD Peptides for Integrin-Subtype-Selective PET/CT Imaging

[ 26 ]Exporter Mdr1 as an importer is an achilles’ heel for combating drug-resistant Candida

[ 27 ]Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation

[ 28 ]Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling

[ 29 ]Leveraging Diverse Bi-Triazine Cross-linkers for Modulating Conformation and Biological Activity of Cyclic and Dimeric Peptides

[ 30 ]ChemR23/PTEN suppresses inflammation in retinal Müller cells and retinal ganglion cell damage in diabetic mice

[ 31 ]Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation

[ 32 ]The nucleotidyl transferase URT1-directed mRNA surveillance is critical for embryo and seedling development in Arabidopsis

[ 33 ]TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury

[ 34 ]Targeting IL-1β to inhibit neutrophil extracellular traps improves meningeal lymphatic dysfunction in cerebral venous sinus thrombosis

[ 35 ]Targeting Osteoporosis-Osteoarthritis Comorbidity: Multi-Omics Identification of SON and Exploration of Therapeutic Agents

[ 36 ]α2-3-Sialylated Glycoproteins Attenuate Streptococcus mutans Virulence and Associated Host Inflammatory Responses

[ 37 ]TRIM31 attenuates microglia-mediated neuroinflammation via targeting TAK1 in vitro and in vivo

[ 38 ]Anti-inflammatory Effect of Gallic Acid on Chronic Bacterial Prostatitis: Involving Target Tissue Distribution

[ 39 ]Ghardaqenoids A–F: Six New Diterpenoids from the South China Sea Soft Coral Heteroxenia ghardaqensis with Lipid-Lowering Activity via the Activation of the AMPK Signaling Pathway

[ 40 ]Oleanolic Acid Ameliorates Hepatic Lipid Metabolism and Autophagy in Type 2 Diabetic Mice via the STAT3 Signaling Pathway

[ 41 ]SPP1 knockdown inhibits invasion, migration and paclitaxel-induced Epithelial-Mesenchymal Transition in Cervical Cancer Cells through the TGF-β/Akt/Snail pathway

[ 42 ]High-Fat Diet Induces Preeclampsia-Like Phenotypes Associated with Impaired Decidualization and NF-κB Activation

[ 43 ]Staphylococcus aureus rewires arginine metabolism to drive mammary aging via macrophage–epithelial crosstalk

[ 44 ]STING-GDF15-STAT3 signaling contributes to neuroinflammation after intracerebral hemorrhage

[ 45 ]The underlying mechanism of scorpion venom peptide BmK AS in reducing epilepsy seizures: mediated through dual modulation of Nav1.6 and the inflammasome pathway

[ 46 ]Semaglutide ameliorates neuroinflammation and cognitive impairment in APP/PS1 mice

[ 47 ]BRSK2 accumulation mediated by TRIM28 accelerates hepatocellular carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway

[ 48 ]The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory

[ 49 ]Untargeted Metabolomics and Metabolite–Gene Network Analysis Predict NF-κB Inhibition in Artemisian B-Treated Triple-Negative Breast Cancer Cells

[ 50 ]Dictamnine Inhibits WNT Pathway and EMT Progression in Prostate Cancer and Remodels the Tumor Microenvironment

[ 51 ]Integrated ATAC-Seq and RNA-Seq Analyses Identify the Motif CGTTTCCGGT as an Arginine Deficiency-Responsive DNA Element in Cancer Cells

[ 52 ]The regulatory role of HIRRV nucleoprotein on STING-mediated interferon response

[ 53 ]Marker gene identification and functional characterization of dendritic cells (DCs)-like in turbot (Scophthalmus maximus)

[ 54 ]Lipid overload triggers PERK-ALCAT1-mediated mitophagy failure in hepatocytes

[ 55 ]SNHG7 interacts with PCBP2 to promote CDKN2A expression and modulate cuproptosis in colorectal cancer

[ 56 ]The Role of HGF/c-Met/PI3K/AKT Pathway Regulated by α7-nAChR/β2-AR in Nicotine-Promoted Malignant Progression of Nonsmall Cell Lung Cancer A549 Cells

[ 57 ]LINC00673-V4 Promotes Colorectal Cancer Cell Proliferation by Interacting With FUS and Restoring the Expression of Hippo-YAP Target Genes

[ 58 ]The Oncogenic Role of Prostate Stem Cell Antigen (PSCA) in Colorectal Cancer: Implications for Targeted Therapy

[ 59 ]Marker genes identification and functional characterization of thrombocytes in turbot (Scophthalmus maximus)

[ 60 ]L-Carnosine Enhances the Proliferation and Myogenic Differentiation of Yanbian Cattle Skeletal Muscle Satellite Cells for Cultured Meat Production via Activating the Akt/mTOR/P70S6K Signaling Pathway

[ 61 ]A colloidal gold immunochromatographic test strip based on McAbs anti-S protein to detect porcine epidemic diarrhea virus

[ 62 ]YAP-induced BICD1 promotes hepatocellular carcinoma cell proliferation, stemness, and migration by facilitating the nuclear translocation of HIF-1α

[ 63 ]Comparative profiling of tangential flow filtration and ultracentrifugation for the scalable production of bovine milk extracellular vesicles

[ 64 ]circ_0006156 promotes esophageal squamous cell carcinoma progression via activation of the TGFβ/Smad pathway

[ 65 ]Sphingolipid metabolic enzyme GLA expression in gliomas: prognostic implications and therapeutic potential

[ 66 ]Acupuncture Inhibits Ferroptosis to Attenuate Cerebral Ischemia-Reperfusion Injury Through FTO-Mediated m6A Modification of ACSL4

[ 67 ]IGF2BP3 promotes diabetic retinopathy development by enhancing SEMA3G mRNA stability

[ 68 ]R-loop-associated regulator VDAC1 drives malignant phenotypes in uveal melanoma

[ 69 ]Targeting FAM64A: a promising strategy to halt liver cancer angiogenesis and enhance immunity

[ 70 ]Bombyx mori BmLis1 inhibits BmNPV replication by promoting the cell cycle G2/M progression

[ 71 ]Multi-Omic and Spatial Profiling Identifies an Epithelial DKK1 Associated with Microenvironmental Remodeling in Pancreatic Ductal Adenocarcinoma

[ 72 ]Tributyl phosphate disrupts hepatic lipid metabolism via cGAS-STING signal pathway mediated inflammation

[ 73 ]UCHL1 Exacerbates Periodontitis by Coordinating Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Macrophages

[ 74 ]Betaine protects bovine granulosa cells from oxidative stress involving STAT3-associated regulation of GSTA5

[ 75 ]High expression of IRF8 in AChR-specific cells regulates the function of B cells

[ 76 ]PDIA2 promotes progression of lung cancer by regulating JNK and caspase-3 signaling pathway

[ 77 ]HECTD4 in human umbilical cord mesenchymal stem cells-derived exosomes alleviates osteoclast differentiation in osteoporosis progression by suppressing RANK m6A modification via promoting METTL3 ubiquitination

[ 78 ]Enhancing Vaccine Immunogenicity of H9N2 Influenza HA by Locking Its Pre-Fusion Conformation via Cleavage Site Engineering

[ 79 ]Luteolin Inhibits Bovine Viral Diarrhea Virus Replication by Disrupting Viral Internalization and Replication and Interfering with the NF-κB/STAT3-NLRP3 Inflammasome Pathway

[ 80 ]Leptospira interrogans HtrA protease is a potent inducer of multifaceted cellular responses

[ 81 ]Mechanism Analysis of the Effect of Cordycepin on Colorectal Cancer via Network Pharmacology and Experiment