Ascochlorin (Ilicicolin D)，又称壳二孢氯素，是从壳二孢菌属发酵培养液滤饼中得到的抗病毒抗生素，是异戊二烯类抗生素，具有抗肿瘤、抗炎活性。Ascochlorin可抑制STAT3信号活性，诱导细胞凋亡。

参考文献

1.Dai X, et al. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Mol Oncol. 2015 Apr;9(4):818-33.

2.Lee SH, et al. Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-κB, ERK1/2, and p38 Signaling Pathway. J Cell Biochem. 2016 Apr;117(4):978-87.

3.Min-Wen JC, et al. Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Adv Protein Chem Struct Biol. 2017;108:199-225.

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