Abstract

Magnesium (Mg) have a promising potential in orthopedic implantations and bone regeneration due to their biodegradation and resemblance modulus to native bone. However, the rapid corrosion/bacterial infection/single function probably limits their application. Herein, we utilized a facile surface self-assembly method to construct a multifunctional elastomeric bioactive poly(citrate-silicon) (PCS) coating on Mg through the ion bonding interaction (–COO-Mg) to obtain the [email protected] implants. Compared to the conventional Mg, [email protected] implants possess representative multifunctional properties including high corrosion resistance, low degradation and stable pH environment, controlled photoluminescence , robust antibacterial activity, enhanced cytocompatibility and osteogenic differentiation ability. The in vivo results suggested that [email protected] showed fluorescence-tracking ability, and could efficiently reduce the inflammatory response and treat the infection of methicillin-resistant Staphylococcus aureus ( MRSA ). This work probably provides a reasonable strategy to develop visual bioactive implants with antiinfection for regenerative medicine.