双重响应中性粒细胞杂交微型机器人的生物安全性评价
Biosafety evaluation of dual-responsive neutrobots
Hongyue Zhang, Liting Wang, Zesheng Li, Yuxing Ji, Zhiguang Wu, Qiang He
Journal：Journal of Materials Chemistry B
IF：7.57
DOI：10.1039/D2TB00938B
PMID：35775603
Published：2022-06-16
research field：肿瘤学分子生物学干细胞生物学
Abstract
The toxicity effects of paclitaxel (PTX)-loaded magnetic neutrophil-hybrid swimming microrobots (“neutrobots”) in vivo were assessed after intravenous administration to mice. The mice after 72 hours exhibited minimal immunotoxicity and liver and kidney toxicity at an administration dose of 3 × 106 PTX-loaded neutrobots. The minor toxicity of drug-loaded neutrobots holds considerable promise for biomedical applications.
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