新型磷酸化甲壳素-羟基磷灰石复合材料促进血管生成和骨生成用于骨缺损修复

Abstract

Current bone repair materials face limitations including donor site morbidity, immune rejection, and insufficient osteogenic capacity. To overcome these challenges, tissue engineering has introduced bioactive composites that better mimic the natural bone microenvironment. Here, we developed a novel composite by integrating phosphorylated chitin, which is an excellent biocompatible and bioactive organic polymer, with biogenic hydroxyapatite, a mineral phase closely resembling native bone. The composite was systematically characterized for its physicochemical properties. In vitro studies demonstrated the angiogenic and osteogenic activities of phosphorylated chitin, which were further enhanced by the introduction of magnesium ions. In vivo experiments using rat calvarial defect and rabbit alveolar defect models confirmed its superior bone regeneration capability, with effective promotion of new bone formation. These results underscore the outstanding osteogenic potential of this composite, offering a promising strategy for effective bone defect repair.