Abstract

Static cold preservation remains a cornerstone of transplantation, and high-performance organ preservation solutions, sharing the same goal as regenerative biomaterials, are indispensable for facilitating the regeneration and functional recovery of organs following transplantation. In this study, we developed a betaine-based organ preservation solution (BOPs), combined with the optimization of osmotic pressure components and energy support components. In the endothelial cell inflammation model, BOPs exhibited robust antioxidative and anti-apoptotic effects. Across multiple stages of kidney transplantation, including static cold storage, early reperfusion, and the post-in situ transplantation period, BOPs demonstrated organ preservation efficacy comparable to that of University of Wisconsin (UW) solution. Owing to the favorable efficacy and cost-effectiveness, BOPs hold broad market prospects.