4-Hydroxytamoxifen ((E/Z)-4-Hydroxytamoxifen),又称4-羟基三苯氧胺,是tamoxifen的活性代谢产物,是(Z)-4-Hydroxytamoxifen和(E)-4-Hydroxytamoxifen的消旋体,是雌激素受体的选择性调节剂,可用于乳腺癌治疗研究。
参考文献
[1] Asp ML, Martindale JJ, Metzger JM. Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling. PLoS One. 2013 Oct 24;8(10):e78768. doi: 10.1371/journal.pone.0078768(IF:2.776).
[2] Beland FA, McDaniel LP, Marques MM. Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo. Carcinogenesis. 1999 Mar;20(3):471-7. doi: 10.1093/carcin/20.3.471(IF:4.004).
[3] Davis KM, Pattanayak V, Thompson DB, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11(5):316-8. doi: 10.1038/nchembio(IF:12.154).
-25~-15℃保存,有效期3年。