_{Thalidomide (Sedoval)，又称沙利度胺，抑制cereblon（cullin-4 E3泛素连接酶复合物CUL4-RBX1-DDB1的一部分），Kd值约为250 nM，具有抗肿瘤活性，是一种镇静药和免疫调节剂，临床上可用于治疗多发性骨髓瘤和各型麻风病。}

参考文献

1.Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.

2.Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.

3.Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

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