AM1241(氨基烷基吲哚类似物) II型大麻素受体(CB2)拮抗剂|CAS 444912-48-5（53922ES）

_{AM1241 (AM-1241)是一种氨基烷基吲哚类似物，是II型大麻素受体(CB2)的选择性拮抗剂，Ki为3.4 nM；作用于CB1受体的Ki为280 nM。大麻素受体CB2主要分布于外周免疫细胞中，调节与免疫相关的各种疾病。}

参考文献

[1] Ibrahim MM, et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10529-33.

[2] Yao BB, et al. In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?. Br J Pharmacol. 2006 Sep;149(2):145-54.

[3] Nackley AG, et al. Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience. 2003;119(3):747-57.

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