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[ 1 ]Divergent tumor immunity determined by bacteria-cancer cell engagement

[ 2 ]ROCK1 inhibition primes anti-tumor immunity in EGFR-mutant NSCLC by triggering PD-L1 degradation mediated by SMURF2

[ 3 ]GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation

[ 4 ]Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling

[ 5 ]Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

[ 6 ]Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

[ 7 ]Poly(Citric Acid) Bidirectional Regulator: Coordinating Iron Homeostasis to Suppress Stress Responses and Boosting Mitochondrial Bioenergetics for Enhanced Nerve Repair

[ 8 ]NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein

[ 9 ]Cryopreservative Bioink Enables Direct Bioprinting of Adherent Cells

[ 10 ]ACSL5 Mediates Adaptation to the Palmitic Acid-Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis

[ 11 ]RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2

[ 12 ]CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy

[ 13 ]NPY-Y2R driven neuroimmune signaling as a potential therapeutic target for trigeminal neuralgia: clinical and experimental evidence

[ 14 ]Harnessing the gut–immune–joint axis: Oral microalgae-based thermoresponsive microspheres enhance intra-articular therapy for rheumatoid arthritis

[ 15 ]A Versatile Nanoplatform Based on Metal-Phenolic Networks Inhibiting Tumor Growth and Metastasis by Combined Starvation/Chemodynamic/Immunotherapy

[ 16 ]SERS/NIR-II Optical Nanoprobes for Multidimensional Tumor Imaging from Living Subjects, Pathology, and Single Cells and Guided NIR-II Photothermal Therapy

[ 17 ]Peptide-Modified Fluorinated Polymeric Carriers for Targeted Delivery of β-GP to Enhance Bone Regeneration

[ 18 ]A Thermoplastic and Visualizable Bone Scaffold Dynamically Enhances Hemostasis and Osteogenesis in Bone Defects

[ 19 ]FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

[ 20 ]WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

[ 21 ]Bioengineered CBD-hBD-3 Fusion Peptide-Functionalized Collagen Scaffold Reprograms Fibroblast Fate to Attenuate Fibrosis and Promote Multilayer Vaginal Regeneration

[ 22 ]A Near-Infrared Light-Responsive ROS Cascade Nanoplatform for Synergistic Therapy Potentiating Antitumor Immune Responses

[ 23 ]Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

[ 24 ]Bacteroides fragilis toxin promotes gall bladder cancer in mice

[ 25 ]Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

[ 26 ]Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development

[ 27 ]Disrupting sympathetic nerve-tumor crosstalk via biomimetic nanovesicles to augment chemotherapy efficacy under chronic stress

[ 28 ]BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression

[ 29 ]PAWR augments anti-RNA viral innate immunity by promoting the PIM2-XBP1s-RIG-I signaling axis

[ 30 ]X-ray preactivated reversible persistent luminescence enables photodynamic immunotherapy of deep tumors

[ 31 ]Combination of PARP and KRASG12D inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC

[ 32 ]Redox-regulated in situ-forming hydrogel informed by single-cell transcriptomics for functional restoration of injured vocal folds

[ 33 ]Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration

[ 34 ]Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

[ 35 ]TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice

[ 36 ]Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking

[ 37 ]Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

[ 38 ]The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis

[ 39 ]Transcriptome Analysis Revealed the Symbiosis Niche of 3D Scaffolds to Accelerate Bone Defect Healing

[ 40 ]A Temporal PROTAC Cocktail-Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells

[ 41 ]Mild photothermal therapy boosts nanomedicine antitumor efficacy by disrupting DNA damage repair pathways and modulating tumor mechanics

[ 42 ]Silk Fibroin Ionotronics for High-Performance Wearable Perovskite LEDs

[ 43 ]Magnetic Graphene for High-Performance Isolation of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes via Ca2+-Dependent Reversible Recognition

[ 44 ]Ultrasmall Enzyme-Powered Janus Nanomotor Working in Blood Circulation System

[ 45 ]TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis

[ 46 ]Metal-phenolic networks-encapsulated cascade amplification delivery nanoparticles overcoming cancer drug resistance via combined starvation/chemodynamic/chemo therapy

[ 47 ]Biological signal integrated microfluidic hydrogel microspheres for promoting bone regeneration

[ 48 ]Excipient-free prodrug-based three-in-one nanoparticles co-deliver diversified agents to amplify tumor therapy

[ 49 ]The highly effective therapy of ovarian cancer by Bismuth-doped oxygen-deficient BaTiO3 with enhanced sono-piezocatalytic effects

[ 50 ]Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis

[ 51 ]N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway

[ 52 ]Metal–Phenolic Networks-Based Nanozyme Reprograms Tumor Metabolism and Immunosuppressive Microenvironment to Enhance Ferroptosis and Potentiate Cancer Immunotherapy

[ 53 ]Atorvastatin-Driven Methuosis in Glioblastoma: A Biomimetic Nanodrug for Targeted Tumor Therapy

[ 54 ]Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

[ 55 ]An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments

[ 56 ]KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition

[ 57 ]Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity

[ 58 ]Overcoming AZD9291 Resistance and Metastasis of NSCLC via Ferroptosis and Multitarget Interference by Nanocatalytic Sensitizer Plus AHP-DRI-12

[ 59 ]Activated Natural Killer Cells-Dependent Dendritic Cells Recruitment and Maturation by Responsive Nanogels for Targeting Pancreatic Cancer Immunotherapy

[ 60 ]Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor-Specific and Ferroptosis-Augmented Sonodynamic Therapy

[ 61 ]Enzyme-responsive microneedle patch for bacterial infection and accelerated healing of diabetic wounds

[ 62 ]GSH-responsive and O2-economizing virus-like nanocapsule for photothermal-augmented sonodynamic therapy

[ 63 ]Selenium-loaded sustained-release schizophyllan alleviates pancreatic and pulmonary inflammatory damage in type 1 diabetes mellitus by modulating gut microbiota and T cell balance

[ 64 ]Nano-armed bcg delivers Cu-Fe MOF to trigger dual cell death in bladder cancer

[ 65 ]A novel nasal mucosal peptide-modified co-delivery system for ginsenoside Rg1, Rb1, and notoginseng saponin R1 in the amelioration of AD

[ 66 ]Nanobodies targeting the Epstein-Barr virus EBNA1 DNA binding domain inhibit tumor growth

[ 67 ]Alleviation of diabetic cardiomyopathy via preventing VCAM1-positive cells from senescence by engineered nanovesicles

[ 68 ]The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription–replication conflicts

[ 69 ]Drynaria roosii-derived exosome-like nanovesicles promote alveolar socket healing via activation of ITPR3-mediated calcium flux

[ 70 ]In-situ ²²³Ra-doped calcium-alginate composite microspheres: a high-LET and immunoactivating platform for α-particle radioembolization in hepatocellular carcinoma

[ 71 ]Targeting the gut–joint axis: an oral Spirulina hydrogel as an adjuvant strategy for rheumatoid arthritis therapy

[ 72 ]Early risperidone exposure impairs cognitive function by perturbation of the gut microbiome and bile acids/tyrosine-PTP1B axis

[ 73 ]Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms

[ 74 ]Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation

[ 75 ]Astragalus-derived nano-agonist potentiates chemotherapy by reducing tumor-suppressive macrophages

[ 76 ]Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution

[ 77 ]Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells

[ 78 ]Tailoring moisture electroactive Ag/Zn@cotton coupled with electrospun PVDF/PS nanofibers for antimicrobial face masks

[ 79 ]Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

[ 80 ]SLC2A3-Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

[ 81 ]Programmable RNA N6,2´-O-Dimethyladenosine Editing

[ 82 ]HSP90AB1-Mediated Ubiquitin-Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress-Induced Autophagy

[ 83 ]Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

[ 84 ]SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

[ 85 ]PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

[ 86 ]DOTA-grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance-reversal Agents (MRRAs) Combating Against New Delhi Metallo-β-lactamase (NDM)-producing Bacteria

[ 87 ]ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling

[ 88 ]Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection

[ 89 ]Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

[ 90 ]Rational Design of Broad-Spectrum Anti-Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

[ 91 ]A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

[ 92 ]Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors

[ 93 ]Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma

[ 94 ]Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy

[ 95 ]Synergistic mechanical and therapeutic modulation of engineered tumor cell-derived microparticles for enhanced cancer treatment

[ 96 ]Erythrocyte patch for enhanced B cell depletion therapy

[ 97 ]FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis

[ 98 ]Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3

[ 99 ]Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis

[ 100 ]Spinal cord tissue engineering via covalent interaction between biomaterials and cells