Abstract

Ovarian cancer (OC) is the leading cause of death of gynecological malignancy. Sonodynamic therapy (SDT) with high penetration ability and minimal invasion is considered a safe method to eliminate deep OC. The development of highly efficient sonosensitizers warrants the successful application of SDT. This work proposed an oxygen-deficient piezoelectric nanocomposite (Bismuth doped oxygen-deficient BaTiO 3 ) as a novel sonosensitizer. The oxygen defect engineering decreased the band gap, and Schottky junction modified by Bismuth(Bi) nanoparticles prompted the transfer and separation of charge carriers and inhibited the recombination under ultrasound irradiation. The in vitro results demonstrated that the Bi doped oxygen-deficient BaTiO 3 could significantly increase the apoptosis of tumor cells because of its high efficiency in generating reactive oxygen species (ROS). RNA sequencing further proved that its antitumor activity might be achieved through the extracellular matrix disassembly pathway. The in vivo study demonstrated that Bi doped oxygen-deficient BaTiO 3 could achieve high SDT efficiency for OC therapy.