Tolvaptan (OPC-41061, OPC41061)，又称托伐普坦，是可口服的、竞争性精氨酸加压素受体2 (vasopressin receptor 2, V2R)拮抗剂，通过阻碍AVP与V2受体结合，抑制AVP诱导的血小板聚集。临床上，Tolvaptan用于治疗心力衰竭和肝硬化低钠血症。

参考文献

[1] Miyazaki T, et al. Tolvaptan, an orally active vasopressin V(2)-receptor antagonist - pharmacology and clinical trials. Cardiovasc Drug Rev. 2007 Spring;25(1):1-13.

[2] Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.

[3] El-Shabrawy M, et al. Protective effect of tolvaptan against cyclophosphamide-induced nephrotoxicity in rat models. Pharmacol Res Perspect. 2020 Oct;8(5):e00659.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。