Spautin-1是一种特效的自噬选择性抑制剂，通过抑制泛素特异性肽酶USP10和USP13的活性，促进III类PI3激酶复合体的降解。Spautin-1可通过抑制自噬，提高放疗和化疗导致的肿瘤细胞死亡率，具有潜在的抗癌作用。

参考文献

1. Liu J, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 2011 Sep 30;147(1):223-34.
2. Shao S, et al. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014 May;44(5):1661-1668.
3. Xiao J, et al. Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Mol Med. 2016 Oct;22:643-652.

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