Chloroquine (Aralen, CHQ, CQ)，又称氯喹，是氨基喹啉类的抗疟药和和抗阿米巴药，也是自噬溶酶体抑制剂。氯喹不能直接杀死疟原虫，通过与核蛋白结合，插入到DNA的双股螺旋之间，从而阻止DNA复制与RNA转录，进而抑制疟原虫繁殖。氯喹还能通过提高溶酶体中pH升高使溶酶体中酸性水解酶失活，从而抑制细胞内自噬溶酶体的融合与降解。

参考文献

1. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
2. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.
3. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001 Feb;20(3):131-5.

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