Brefeldin A，又名BFA, Cyanein, Decumbin, 布雷非德菌素 A，是一种常用的可逆性蛋白转运抑制剂，一种真菌代谢产物，可破坏高尔基体的结构并抑制其功能，进而特异地阻断蛋白质从内质网(ER)向高尔基体(Golgi)的转运。BFA可抑制coat proteins（如β-COP and ADP-ribosylation factor (ARF)）与高尔基体的结合并抑制GDP-GTP交换。

Brefeldin A也常被用于抑制细胞因子等蛋白的分泌，并用于增强分泌蛋白的免疫染色检测。Brefeldin A可激活神经鞘磷脂循环(sphingomyelin cycle)，还可诱导一些肿瘤细胞发生凋亡。

客户使用本产品发表的科研文献（部分）

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[2] Zhang S, Wang C, et al. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Cell Rep. 2020 Jul 7;32(1):107879. doi: 10.1016/j.celrep.2020.107879. PMID: 32640214.

[3] Lin DL, Yao HY, et al. Phospholipase D-derived phosphatidic acid promotes root hair development under phosphorus deficiency by suppressing vacuolar degradation of PIN-FORMED2. New Phytol. 2020 Apr;226(1):142-155. doi: 10.1111/nph.16330. Epub 2019 Dec 19. PMID: 31745997; PMCID: PMC7065129.

[4] Ma H, Tan Y, Wen D, et al. DC-CTL targeting carbonic anhydrase IX gene combined with iAPA therapy in the treatment of renal cell carcinoma. Hum Vaccin Immunother. 2021 Nov 2;17(11):4363-4373. doi: 10.1080/21645515.2021.1955610. Epub 2021 Dec 1. PMID: 34851805; PMCID: PMC8828120.

[5] Zhao M, Duan N, Wang Y, et al. CD5+ B lymphocytes secrete IL-10 rather than TGF-β1 which control the immune response in autoimmune haemolytic anaemia/Evans syndrome[J]. Autoimmunity, 2019, 52(1): 12-20.

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