分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
重组蛋白
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高通量测序建库
病原检测UCF系列
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Recombinant Human HVEM/TNFRSF14 (His Tag)
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产品介绍

HVEM (herpesvirus entry mediator), also known as TNFRSF14 and CD270, is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. Mature human HVEM consists of a 164 aa extracellular domain (ECD) with three cysteine-rich domains (CRD), a 21 aa transmembrane segment, and a 60 aa cytoplasmic tail with a TRAF interaction domain. Within the ECD, human HVEM shares 55% aa sequence identity with mouse and rat HVEM. Alternative splicing generates an additional isoform with a substitution of the N-terminal 10 amino acids including the signal peptide. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. Its expression declines during effector T cell activation but is up-regulated during Treg activation. HVEM functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha.

产品性质
产品特色

高纯度、高活性、低内毒素、高批间一致性

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Tris-Bis PAGE

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存储条件

-25 ~ -15℃保存,收到货之后有效期1年。 复溶后, 无菌条件下,-85 ~ -65℃保存,3个月有效期。

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