cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, c GAMP) cGAMP可上调细胞骨髓中的血清抗PA、IgA和IgA水平，也可促进白细胞介素-1 (IL1)，白细胞介素-6 (IL6)或肿瘤坏死因子(TNF)的基因的转录水平，激活内质网(ER)内源性受体STING，诱导抗病毒状态和I型IFN的分泌。 

参考文献

[1]. Liu Y, Jesus AA, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-518.

[2]. Ablasser A, Schmid-Burgk JL, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.

[3]. Martin TL, Jee J, et al. Sublingual targeting of STING with 3'3'-cGAMP promotes systemic and mucosal immunity against anthrax toxins. Vaccine. 2017 Apr 25;35(18):2511-2519.

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