Oncometabolite 2-hydroxyglutarate destabilizes CDH1 to regulate quiescence and enhance chemotherapy sensitivity
Zhang Hai-Hui, Chen Xiang-Tian, Li Si-Qi, Yan Xin-Lei, Wang Meng, Lin Yan, Yuan Yi-Yuan, Mao Yun-Zi, Liu Jie, Xu Wei
Journal：Cell Communication and Signaling
IF：11.6
DOI：10.1186/s12964-026-02988-9
PMID：
Published：2026-06-10
research field：肿瘤学分子生物学细胞生物学代谢癌症生物学分子肿瘤学细胞周期调控泛素-蛋白酶体系统信号转导化疗耐药
Abstract
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