Isatin是一种多靶点生物活性分子,能有效抑制单胺氧化酶,并拮抗心房钠尿肽及一氧化氮刺激的鸟苷酸环化酶。此外,它可与中枢苯二氮卓受体结合,并对5-羟色胺系统产生影响。
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英文别名 (English Synonym) |
Isatin |
|
中文名称 (Chinese Name) |
靛红；吲哚-2,3-二酮；板蓝根 |
|
靶点 (Target) |
MAO |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
91-56-5 |
|
分子式 (Formula) |
C8H5NO2 |
|
分子量 (Molecular Weight) |
147.13 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Igosheva N, Lorz C, O'Conner E, Glover V, Mehmet H. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug,47(3):216-24. doi: 10.1016/j.neuint.2005.02.011. PMID: 15876476.[2]McIntyre IM, Norman TR. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990,79(1-2):35-40. doi: 10.1007/BF01250998. PMID: 1688707.
