Clemizole hydrochloride,又称盐酸克立咪唑,是组胺受体(H1 receptor)拮抗剂,通过抑制NS4B的RNA结合表现出抗丙型肝炎(HCV)病毒的活性。
参考文献
[1] Einav S, Gerber D, Bryson PD, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27. doi: 10.1038/nbt.1490(IF:31.864).
[2] Nishimura T, Hu Y, Wu M, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96. doi: 10.1124/jpet.112.198697(IF:3.615).
[3] Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. doi: 10.1124/mol.114.093229(IF:3.853).
-25~-15℃保存,有效期3年。





