南美超级胎牛血清999尝鲜特惠
N-糖基化SGK196通过PI3K/AKT/GSK3β通路抑制基底样乳腺癌转移
N-glycosylated SGK196 suppresses the metastasis of basal-like breast cancer cells
Xu Ci, Zhang Meichao, Bian Lei, Li Yanyan, Yao Yuan, Li Dong
Journal：Oncogenesis
IF：6.12
DOI：10.1038/s41389-019-0188-1
PMID：31913260
Published：2020-01-08
research field：食品微生物学乳品科学食品安全分子诊断应用微生物学
Abstract
SGK196 is a protein O -mannose kinase involved in an indispensable phosphorylation step during laminin-binding glycan synthesis on alpha-dystroglycan (α-DG). However, the function of SGK196 in cancer diseases remains elusive. In the current study, we demonstrated that SGK196 is primarily modified by N-glycosylation in breast cancer (BC) cells. Furthermore, gain and loss-of-function studies showed that N-glycosylated SGK196 suppresses cell migration, invasion, and metastasis in BC, particularly in the basal-like breast cancer (BLBC) type. In addition, we found that SGK196 N-glycosylation performs the regulatory function through the PI3K/AKT/GSK3β signaling pathway. Collectively, our results show that N-glycosylated SGK196 plays suppression roles in BLBC metastases, therefore providing new insights into SGK196 function in BC.
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