[ 1 ]TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile

[ 2 ]Engineered immunosuppressive dendritic cells protect against cardiac remodelling

[ 3 ]A broadly protective antibody targeting gammaherpesvirus gB

[ 4 ]Mechanism of activation and biased signaling in complement receptor C5aR1

[ 5 ]Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability

[ 6 ]A Unique Intercellular Feedforward Loop From HK1 to TGF‐β1 Promotes the Progression of Hepatocellular Carcinoma

[ 7 ]METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability

[ 8 ]The PI4K2A-OSBPL6/ORP6-PS axis mediates lysosomal membrane repair to restore neuronal lipid homeostasis and promote neuronal survival after spinal cord injury

[ 9 ]Establishing a long-term versatile culture system for functional mouse mammary organoids from single cells

[ 10 ]EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling

[ 11 ]Extracellular vesicle engineering using a small scaffold protein

[ 12 ]Optical control of the cardiac rhythm with photoswitchable NaV1.5 channel blockers

[ 13 ]Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression

[ 14 ]Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Block Pyroptosis in Endotoxin-Induced Sepsis

[ 15 ]Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions

[ 16 ]Automated high-throughput genome editing platform with an AI learning in situ prediction model

[ 17 ]Targeting myofibroblast copper vulnerability reverses pulmonary fibrosis via METTL3-directed STAT6 m6A driving cuproptosis

[ 18 ]Insights into membrane association of the SMP domain of extended synaptotagmin

[ 19 ]Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly

[ 20 ]TRPV1 and TRPA1 channels exhibit bifurcated sensing of singlet oxygen and hydrogen peroxide

[ 21 ]Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease

[ 22 ]Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins

[ 23 ]Molecular insights into mRNA export regulation by the human TREX-2 complex

[ 24 ]Miniature and versatile genome regulation TnpB-ωRNA toolkits facilitate cancer immunotherapy

[ 25 ]Transition metal-enhanced immunity in Arabidopsis roots via an NLR pair

[ 26 ]Targeted inhibition of ITK activity with anti-CD3 antibody-modified calcium silicate nanoparticles loaded with novel 7H-Pyrrolo[2,3-d]pyrimidine derivatives for treating aplastic anemia

[ 27 ]APRIL-driven BCMA/TACI dual-targeted ligand–drug conjugates for selective and potent therapy of multiple myeloma

[ 28 ]Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

[ 29 ]Programmable RNA N6,2´-O-Dimethyladenosine Editing

[ 30 ]Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

[ 31 ]A Non-Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

[ 32 ]Structure-Guided Engineering of a Cas12i Nuclease Unlocks Near-PAMless Genome Editing

[ 33 ]ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling

[ 34 ]Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8+ T cell immunity via rewiring MHC-I antigen presentation

[ 35 ]mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy

[ 36 ]Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex

[ 37 ]TUFT1 stabilizes TGF-β receptor II protein and facilitates activation of hepatic stellate cells into metastasis-promoting myofibroblasts

[ 38 ]Discovery of a novel Nrf2 activator that modulates mitochondrial function in neurons by regulating DHRS3-Nrf2 interaction after ischemic stroke

[ 39 ]Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model

[ 40 ]CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation

[ 41 ]Phase separation of p85β modulates hepatocellular carcinoma progression through POLR1A

[ 42 ]Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment

[ 43 ]Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

[ 44 ]The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma

[ 45 ]Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury

[ 46 ]Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages

[ 47 ]High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV

[ 48 ]STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway

[ 49 ]Ligustilide Alleviates Renal Fibrosis Through Fblim1-Dependent Inhibition of the TGF-β1/Smad3 Signaling Pathway

[ 50 ]Saikosaponin D Regulates HK2-Mediated Glycolytic Lactate Signaling to Alleviate CKD-Induced Renal Fibrosis

[ 51 ]Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

[ 52 ]Spy&IAC enables specific capture of SpyTagged proteins for rapid assembly of plug-and-display nanoparticle vaccines

[ 53 ]Depicting the dynamic transcriptional and epigenetic landscape of testis development in pubertal Simmental cattle

[ 54 ]Bio-engineered nano-vesicles for IR820 delivery: a therapy platform for cancer by surgery and photothermal therapy

[ 55 ]Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups

[ 56 ]Potent and Persistent Antibody Response in COVID-19 Recovered Patients

[ 57 ]Discovery of 2H-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy

[ 58 ]Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

[ 59 ]ADH4 deficiency activates the NRF2-CSF1 axis by increased lipid peroxidation in hepatocellular carcinoma

[ 60 ]Liquid-liquid phase separation-driven molecular subtyping and prognostic modeling in colorectal cancer

[ 61 ]Shared immune dysregulation in systemic lupus erythematosus and colorectal cancer: a multi-omics guided discovery of DNASE1L3-centric efferocytosis deficiency

[ 62 ]Loss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and histone modifications in Treg cells

[ 63 ]Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling

[ 64 ]LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

[ 65 ]The transmembrane segments of SARS-CoV-2 nsp3 govern viral intracellular trafficking

[ 66 ]Soluble programmed death ligand-1-induced immunosuppressive effects on chimeric antigen receptor-natural killer cells targeting Glypican-3 in hepatocellular carcinoma

[ 67 ]Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism

[ 68 ]Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation

[ 69 ]Dissection of the EIAV Core Packaging Region Identifies SL2 Stem and SL2-SL3 Junction as Gag-Associated Packaging Determinants and Antiviral Targets

[ 70 ]UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment

[ 71 ]Eupatilin Ameliorates Hepatic Fibrosis and Hepatic Stellate Cell Activation by Suppressing β-catenin/PAI-1 Pathway

[ 72 ]Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells

[ 73 ]Generation of iVero.219-mcRTA: a doxycycline-inducible high-titer KSHV producer cell line with multicopy orf50 integration

[ 74 ]Curdione alleviates renal fibrosis through Fblim1-dependent inhibition of the TGF-β1/Smad3 signaling pathway

[ 75 ]Dusp22 deficiency in cardiomyocytes exacerbates doxorubicin-induced cardiotoxicity by aggravating mitochondria-dependent apoptosis via JNK pathway

[ 76 ]Lentiviral Dendritic Cell Vaccine Targeting Claudin-18.2 Elicits Potent Antitumor Immunity Against Gastric Cancer

[ 77 ]NCEH1 promotes breast cancer progression by regulating NRP1 and activating the TNF-α/NF-κB signalling pathway

[ 78 ]Structural and Functional Basis of SSTR5 Homodimerization in Controlling Receptor Signaling and Pasireotide Response in Corticotroph Adenomas

[ 79 ]Black carp ubiquitin-conjugating enzyme variant 2 regulates type I IFN production via ubiquitin-mediated degradation of key transcription factors

[ 80 ]Molecular mechanisms and therapeutic strategies for the recurrent F9 (c.520 + 13 A > G) variant in hemophilia B

[ 81 ]SIRT7 safeguards ERα proteostasis via deacetylation-dependent degradation of unliganded and misfolded receptors

[ 82 ]Structure-guided design of a minimal epitope tag and nanobody affinity system

[ 83 ]Elucidating the Molecular Mechanism of 3D1 Antibody Binding to a Swine Enteric Coronavirus Antigen

[ 84 ]Synergistic actions on hHv1 proton channel gating by singlet oxygen-mediated photodynamic modification, voltage, pH, and subunit cooperativity

[ 85 ]LDHA promotes osteoblast differentiation through histone lactylation

[ 86 ]Targeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen

[ 87 ]Iron-quercetin complex ameliorates chronic kidney disease via inhibiting the renal TGF-β1/Smad3/Egr1 axis-mediated kidney injury and fibrosis

[ 88 ]Biolayer interferometry-based detection of engineered extracellular vesicles binding to type I collagen

[ 89 ]Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV

[ 90 ]Cervical cancer derived extracellular vesicles expressed higher level of CD24 and suppressed the phagocytosis of macrophages

[ 91 ]YTHDF1 impacts cardiomyocyte differentiation by regulating the TET2 mRNA

[ 92 ]Co-activating the intrinsic FcRγ/TLR4 signaling axis enhances the antitumor activity of NKG2D CAR-macrophages against prostate cancer

[ 93 ]The intermolecular disulfide bonds of GP64 in Bombyx mori nucleopolyhedrovirus (BmNPV) are essential for its trimerization and virus infectivity

[ 94 ]miR-491-5p Inhibits Emilin 1 to Promote Fibroblasts Proliferation and Fibrosis in Gluteal Muscle Contracture via TGF-β1/Smad2 Pathway

[ 95 ]A multi-omics prognostic model and functional validation of HPGD in clear cell renal cell carcinoma