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动物实验系列产品-选购指南

 
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客户案例
 

 

 
客户文献
 

 

人类疾病的发展十分复杂,以人本身作为实验对象来深入探讨疾病发生机制,推动医药学的发展来之缓慢,借助于动物模型的间接研究,可以有意识地改变那些在自然条件下不可能或不易排除的因素,以便更准确地观察模型的实验结果并与人类疾病进行比较研究,有助于更方便、更有效地认识人类疾病的发生发展规律,研究防治措施。

 

选择指南

模型名称

建模产品

溶解试剂

模型验证

建模方法

溃疡性结肠炎

DSSCat# 60316ES)

蒸馏水

粪便DNA提取试剂盒Cat#18820ES

磁珠法48孔土壤 /

粪便DNA提取试剂盒FA(预封装)

Cat#18528ES

磁珠法土壤/粪便DNA提取试剂盒

Cat#18526ES

H&E染色Cat# 60524ES

尿粪隐血检测Cat# 60403ES

AB-PAS染色液Cat# 60534ES)

  1. ASACat# 60317ES

柳氮磺吡啶Cat# 60320ES)

5-氟尿嘧啶Cat# 51412ES)

点击详情

急性肝损伤

TAACat# 60395ES)

氯化钠(Cat# 60372ES)

H&E染色Cat# 60524ES

Masson染色(Cat# 60532ES

点击详情

溶血性贫血

APH(Cat# 60396ES)

氯化钠(Cat# 60372ES)

H&E染色Cat# 60524ES

点击详情

胰腺炎

牛磺胆酸钠(Cat# 60398ES)

 

H&E染色Cat# 60524ES)

点击详情

雨蛙素Cat# 60321ES)

氯化钠(Cat# 60372ES)

点击详情

L-精氨酸Cat# 61302ES)

 

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糖尿病

STZCat# 60256ES)

柠檬酸一水Cat# 60347ES

柠檬酸三钠二水Cat# 60348ES

H&E染色Cat# 60524ES)

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阿脲 一水合物(Cat# 60331ES)

氯化钠(Cat# 60372ES)

H&E染色Cat# 60524ES)

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帕金森

鱼藤酮

(Cat# 60393ES)-粉末

(Cat# 60394ES)-溶液

DMSOCat# 60313ES)

氯化钠(Cat# 60372ES)

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MPTP

(Cat# 60388ES)-粉末

(Cat# 60387ES)-溶液

氯化钠(Cat# 60372ES)

/

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口腔癌

4-NQOCat# 60392ES

蒸馏水

H&E染色Cat# 60524ES)

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胃癌

MNNGCat# 60397ES)

DMSOCat# 60313ES)

H&E染色Cat# 60524ES)

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高血压

L-NAME hydrochloride

Cat# 52302ES)

蒸馏水

氯化钠(Cat# 60372ES)

H&E染色Cat# 60524ES)

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Angiotensin II human

Cat# 54041ES)

Deoxycorticosterone Acetate

Cat# 54344ES)

类风湿关节炎

弗氏完全佐剂(CFA)

Cat# 60718ES)

蒸馏水

H&E染色Cat# 60524ES)

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弗氏不完全佐剂(IFA)

Cat# 60719ES)

活细胞长期示踪剂

(可用于评估体内/体外大分子对

半透膜的通透性、心血管、微循环、

细胞单层空隙/运动、灌注、

细胞膜渗透性、细胞内吞、

结肠炎的研究)

FITC-Dextran

FITC-Dextran(MW 4000)

Cat#61220ES)

FITC-Dextran (MW 10000)

Cat#61221ES)

FITC-Dextran (MW 20000)

Cat#61222ES)

FITC-Dextran (MW 40000)

Cat#61223ES)

FITC-Dextran (MW 70000)

Cat#61224ES)

FITC-Dextran (MW 150000)

Cat#61225ES) 

蒸馏水

PBS粉末Cat# 60158ES

PBS液体Cat# 41403ES)

氯化钠(Cat# 60372ES)

 

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Antonia Red-Dextran

Antonia Red-Dextran(MW4000)

Cat#61226ES)

Antonia Red-Dextran(MW20000)

Cat#61227ES)

Antonia Red-Dextran(MW40000)

Cat#61228ES)

Antonia Red-Dextran(MW150000)

Cat#61229ES)

TRITC-Dextran

TRITC-Dextran(MW4000)

Cat#61230ES)

TRITC-Dextran(MW20000)

Cat#61231ES)

TRITC-Dextran(MW40000)

Cat#61232ES)

TRITC-Dextran(MW70000)

Cat#61233ES)

TRITC-Dextran(MW150000)

Cat#61234ES)

TRITC-Dextran(MW500000)

Cat#61235ES)

TRITC-Dextran(MW2000000)

Cat#61236ES)

动物麻醉剂

2,2,2-Tribromoethanol(TBE)2,2,2-三溴乙醇

Cat#60727ES)

蒸馏水

 

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脂多糖(LPS)炎症模型

(急性肺损伤;急性胰腺炎;

急性肝衰竭;牙周炎;败血症模型等)

LPS,from Escherichia coli

O55:B5 脂多糖来源于大肠杆菌O55:B5

Cat#60747ES)

LPS,from Escherichia coli

O111:B4 脂多糖来源于大肠杆菌O111:B4

Cat#60748ES)

蒸馏水

H&E染色Cat# 60524ES)

阿利新蓝-过碘酸雪夫(AB-PAS)染色液

Cat# 60534ES)

点击详情

 

 

 

 

客户案例

1.DSS(Cat# 60316ES)——含硫量16-20%,游离硫<0.2%,模拟人UC模型,安全高效

1 结肠炎H&E染色结果

 

客户1:

客户来源:南京农业大学

动物类型:C57BL/6小鼠

造模方法:3% (w/v) DSS自由饮用7天

引用自:doi.org/10.1016/j.jnutbio.2020.108438

2 结肠癌H&E染色结果

客户2:

客户来源:暨南大学

动物类型:BALB/c小鼠

造模方法:

1.10 mg/kg AOM处理小鼠后用纯水自由饮1周;

2.2.5%w/v)DSS自由饮用1周,换纯水自由饮用2周;

3.步骤2重复3次。

引用自:doi: 10.3389/fphar.2020.586885

 

2.雨蛙素(Cat# 60321ES)——十肽分子形式,纯度(HPLC)≥97%

3 胰腺H&E染色结果

客户3:

客户来源:上海交通大学医学院

实验动物:Balb/c小鼠

造模方法:1小时间隔腹腔注射7次50 μg/kg雨蛙素并在最后一次同时注LPS (10 mg/kg)诱导SAP

引用自:doi.org/10.1016/j. ebiom.2022.103959

 

 

3.STZ(Cat# 60256ES)——链脲佐菌素,纯度(HPLC)≥98%

4 各器官H&E染色结果

客户4:

客户来源:华中科技大学同济医学院

引用自:DOI: 10.1021/acsami.1c24569

 

 

 

 

客户文献

 

向下滑动查看

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[2] Lingjun Tong, Haining Hao, Zhe Zhang,et al.Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota[J].Theranostics.2021; 11(17): 8570-8586 IF=11.556

[3] Li, Y., Dong, J., Xiao, H., Zhang, S., Wang, B., Cui, M., & Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes,.2020 .1–18.IF=10.245

[4] Jingjing Gan, Yuxiao Liu, Lingyu Sun,et al.Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment[J].Applied Materials Today.2021 Dec;25:101231 IF=10.041

[5] Mengmeng Xu, Ying Kong, Nannan Chen,et al.Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis[J].Frontiers in Immunology.2022; 13: 855645. IF=7.561

[6] JialiDong,YuanLi,HuiwenXiao,et al.Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models[J].Cell reports.2021, 109886.IF=9.423

[7] Hao H,  Zhang X,  Tong L,  Liu Q,et al.Lactobacillus plantarumEffect of Extracellular Vesicles Derived From  Q7 on Gut Microbiota and Ulcerative Colitis in Mice[J].Frontiers in Immunology.2021.777147 .IF=7.561

[8] Yaohua Fan,Yanqun Fan,Kunfeng Liu,et al.Edible Bird’s Nest Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice by Restoring the Th17/Treg Cell Balance[J].Frontiers in Pharmacology.2021.632602.IF=7.561

[9] Jia-Rong Huang, Sheng-Te Wang, Meng-Ning Wei,et al.Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer[J].Frontiers in Pharmacology.2020.586885. IF=7.561

[10] Gao X, Fan W, Tan L, et al. Soy isoflavones ameliorate experimental colitis by targeting ERα/NLRP3 inflammasome pathways[J]. The Journal of Nutritional Biochemistry, 2020, 83.IF=6.048

[11] Lujuan Xing, Lijuan Fu, Songmin Cao,et al.The Anti-Inflammatory Effect of Bovine Bone-Gelatin-Derived Peptides in LPS-Induced RAW264.7 Macrophages Cells and Dextran Sulfate Sodium-Induced C57BL/6 Mice[J]. Nutrients 2022, 14, 1479. IF=5.717

[12] Wang S,  Huang J,  Tan KS, et al.Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-B Pathway[J].Oxidative Medicine and Cellular Longevity. 2022,4636618. IF=5.076

[13] Xi Z, Ahmad E, Zhang W, et al. Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery. J Control  Release. 2022;342:1-13. doi:10.1016/j.jconrel.2021.11.045 IF=9.776
[14] Xu Z, Liu Y, Ma R, et al. Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration. ACS Appl Mater Interfaces. 2022;14(12):14059-14071. doi:10.1021/acsami.1c24569(IF:9.229)
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[16] Zhang Y, Zhang Y, Halemahebai G, Tian L, Dong H, Aisker G. Urolithin A, a pomegranate metabolite, protects pancreatic β cells from apoptosis by activating autophagy. J Ethnopharmacol. 2021;272:113628. doi:10.1016/j.jep.2020.113628(IF:3.690)
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