Tranilast (MK-341)是一种抗变态反应剂,具有抗炎和免疫调节作用。它能抑制前列腺素D2 (PGD2) 的产生,其钠盐形式可拮抗血管紧张素II并抑制其在血管平滑肌中的生物学效应。
|
英文别名 (English Synonym) |
Tranilast |
|
中文名称 (Chinese Name) |
曲尼司特 |
|
靶点 (Target) |
Angiotensin Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
53902-12-8 |
|
分子式 (Formula) |
C18H17NO5 |
|
分子量 (Molecular Weight) |
327.33 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Darakhshan S, Ghanbari A. Tranilast enhances the anti-tumor effects of tamoxifen on human breast cancer cells in vitro. J Biomed Sci. 2013 Oct 21,20(1):76. doi: 10.1186/1423-0127-20-76. PMID: 24143895, PMCID: PMC3819182.[2]Isaji M, Miyata H, Ajisawa Y, Takehana Y, Yoshimura N. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br J Pharmacol. 1997 Nov,122(6):1061-6. doi: 10.1038/sj.bjp.0701493. PMID: 9401770, PMCID: PMC1565049.
