Hydroxyzine dihydrochloride是一种口服活性的苯二氮卓抗组胺剂,作为组胺H1受体和血清素拮抗剂,具有抗焦虑作用,可用于广泛性焦虑障碍研究。
|
英文别名 (English Synonym) |
Hydroxyzine 2HCl |
|
中文名称 (Chinese Name) |
盐酸羟嗪 |
|
靶点 (Target) |
Histamine Receptor |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
2192-20-3 |
|
分子式 (Formula) |
C21H27ClN2O2·2HCl |
|
分子量 (Molecular Weight) |
447.83 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Minogiannis P, El-Mansoury M, Betances JA, Sant GR, Theoharides TC. Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol. 1998 Oct,20(10):553-63. doi: 10.1016/s0192-0561(98)00054-x. PMID: 9839659.[2]Sawantdesai NS, Kale PP, Savai J. Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice. J Basic Clin Pharm. 2016 Sep,7(4):97-104. doi: 10.4103/0976-0105.189429. PMID: 27999468, PMCID: PMC5153890.
