Meclizine dihydrochloride是一种哌嗪类H1抗组胺剂,可逆地阻断组胺与H1受体结合。它具有抗晕车活性,能透过血脑屏障,并可调节人和小鼠的组成型雄甾烷受体（CAR）,适用于多聚谷氨酰胺毒性障碍（如亨廷顿舞蹈症）的研究。
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英文别名 (English Synonym) |
Meclizine 2HCl |
|
中文名称 (Chinese Name) |
盐酸美克洛嗪 |
|
靶点 (Target) |
Histamine Receptor |
|
通路 (Pathway) |
Neuroscience |
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CAS号 (CAS NO.) |
1104-22-9 |
|
分子式 (Formula) |
C25H27Cl2N2·2HCl |
|
分子量 (Molecular Weight) |
463.87 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha VK. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15,20(2):294-300. doi: 10.1093/hmg/ddq464. Epub 2010 Oct 25. PMID: 20977989, PMCID: PMC3005902.[2]Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29,2(9):1090-101. doi: 10.1016/j.ebiom.2015.07.035. PMID: 26501107, PMCID: PMC4588407.
