Manidipine dihydrochloride不仅能有效降压、改善胰岛素敏感性、保护肾脏及抗动脉粥样硬化,还具有NF-κB介导的抗炎及钙通道抑制相关的抗病毒活性。这种口服亲脂性钙通道拮抗剂被广泛应用于心血管、代谢及感染研究。
|
英文别名 (English Synonym) |
Manidipine 2HCl |
|
中文名称 (Chinese Name) |
盐酸美尼地平 |
|
靶点 (Target) |
Calcium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
89226-75-5 |
|
分子式 (Formula) |
C35H40Cl2N4O6 |
|
分子量 (Molecular Weight) |
683.62 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Costa S, Zimetti F, Pedrelli M, Cremonesi G, Bernini F. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep,62(3):265-70. doi: 10.1016/j.phrs.2010.03.004. Epub 2010 Mar 27. PMID: 20347984.[2]Urata S, Yoshikawa R, Yasuda J. Calcium Influx Regulates the Replication of Several Negative-Strand RNA Viruses Including Severe Fever with Thrombocytopenia Syndrome Virus. J Virol. 2023 Mar 30,97(3):e0001523. doi: 10.1128/jvi.00015-23. Epub 2023 Feb 16. PMID: 36794941, PMCID: PMC10062178.
