溴化潘库溴铵是一种双季铵盐类固醇类神经肌肉松弛剂，其通过竞争性拮抗nACh受体上的乙酰胆碱结合位点来阻断神经肌肉传递；此外，它还能抑制心脏毒蕈碱受体并产生拟交感神经作用。
|
英文别名 (English Synonym) |
Pancuronium dibromide |
|
中文名称 (Chinese Name) |
泮库溴铵 |
|
靶点 (Target) |
AChR |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
15500-66-0 |
|
分子式 (Formula) |
C35H60N2O4·2Br |
|
分子量 (Molecular Weight) |
732.67 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Maestrone E, Magnelli V, Nobile M, Usai C. Extracellular pancuronium affects sodium current in chick embryo sensory neurones. Br J Pharmacol. 1994 Jan;111(1):283-7. doi: 10.1111/j.1476-5381.1994.tb14057.x. PMID: 8012707; PMCID: PMC1910030.[2]Fryer AD, Maclagan J. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):367-71. doi: 10.1007/BF00165549. PMID: 3600815.
