嘧啶合成抑制剂|Leflunomide 来氟米特 异噁唑类免疫抑制剂|CAS 75706-12-6（54631ES）

Leflunomide，又称来氟米特，是异噁唑类免疫抑制剂，也是一种嘧啶合成抑制剂，通过抑制二氢乳清酸脱氢酶(dihydroorotate dehydrogenase)终止DNA和RNA的生物合成，进而抑制细胞增殖，临床上主要用于治疗风湿性关节炎等自身免疫性疾病。

参考文献

[1] Davis JP, Cain GA, Pitts WJ, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35(4):1270-3. doi: 10.1021/bi952168g(IF:2.952).

[2] Xu X, Williams JW, Bremer EG, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270(21):12398-403. doi: 10.1074/jbc.270.21.12398(IF:4.106).

[3] Fox RI, Herrmann ML, Frangou CG, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93(3):198-208. doi: 10.1006/clim.1999.4777(IF:3.548).

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