Folinic acid calcium salt pentahydrate，又称亚叶酸钙五水合物，是一种还原型叶酸，用作叶酸拮抗剂的解毒剂，临床上常用于预防甲氨蝶呤过量所引起的毒性。

参考文献

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[2] Park JG, Collins JM, Gazdar AF, et al. Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines. J Natl Cancer Inst. 1988 Dec 7;80(19):1560-4. doi: 10.1093/jnci/80.19.1560(IF:10.211).

[3] Farrugia DC, Aherne GW, Brunton L, et al. Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies. Clin Cancer Res. 2000 Sep;6(9):3646-56(IF:8.911).

-25~-15℃保存，有效期3年。