OX40 is a T cell co-stimulatory molecule of the TNF receptor superfamily. Its interaction with OX40L plays an important role in the expansion and survival of antigen-specific T cells. OX40 is mainly expressed by CD4+ and CD8+ T cells, and requires the combination of antigen-presenting cells and TCR and the co-stimulation of CD40-CD40 ligand and CD28-B7. OX40-OX40L interactions have been found to be important in the regulation of T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases, making them attractive candidates for clinical intervention.

 

性能参数

Synonyms	TNFRSF4,OX40,CD134,OX40L receptor,ACT35,TXGP1L
Uniprot No.	P43489-1
Source	Recombinant Human OX40 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Leu29 - Ala216
Molecular Weight	The protein has a predicted MW of 21.24 kDa. And it migrates as 30-43  kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity	> 95% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per 1μg of the protein by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution	Centrifuge tubes before opening.The concentration of protein solution used for lyophilization is generally 1mg/mL. Dissolve lyophilized protein with sterile water to ensure the concentration is greater than 100 μg/mL.

 

储存条件

The product should be stored at -25~-15℃ for 1 year from date of receipt.

2-7 days, 2 ~8 °C under sterile conditions after reconstitution.

3 months, -25~-15℃ under sterile conditions after reconstitution.

Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

 

注意事项

1.Please operate with lab coats and disposable gloves,for your safety.

2.This product is for research use only.

 

产品数据

 

Ver. CN20230322