Resibufogenin (Bufogenin, Recibufogenin, RBG),又称布福吉宁、酯蟾毒配基、脂蟾毒甙元或蟾力苏,是华蟾素的干燥分泌物成分,是有毒物质,具有抗肿瘤活性。Resibufogenin可通过诱导ROS累积促进细胞凋亡。Resibufogenin也是Na+/K+-ATP酶抑制剂。
参考文献
1.Hao S, et al. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol In Vitro. 2011 Dec;25(8):1644-53.
2.Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy. 2012;31(1):70-8.
3.Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851.
4.Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug 26;501(2):112-6.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。