Bisindolylmaleimide I（GF109203X; GF-109203X; Go 6850; Go6850; 双吲哚马来酰亚胺I）是一种高效选择性的PKC抑制剂，Ki值为14 nM。GF 109203X抑制PKCα、PKCβI、PKCβII和PKCγ的活性，其IC₅₀值分别为20 nM、17 nM、16 nM和20 nM。

参考文献

[1] Gekeler V, et al. Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance. Br J Cancer. 1996 Sep;74(6):897-905.

[2] Park YS, Cho NJ. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012 Nov;370(1-2):191-8.

[3] Souza AL, et al. In vivo evidence for a role of protein kinase C in peripheral nociceptive processing. Br J Pharmacol. 2002 Jan;135(1):239-47.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。