IDE2 (IDE-2, Definitive Endoderm 2 Inducer)是一种细胞通透的定形内胚层形成诱导剂，效率高于常用的内胚层蛋白诱导剂Activin A或Nodal。IDE2通过促进SMAD2磷酸化和NODAL表达诱导小鼠和人类胚胎干细胞(ESCs)的分化。

参考文献

[1] Borowiak M, Maehr R, Chen S, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009 Apr 3;4(4):348-58. doi: 10.1016/j.stem.2009.01.014(IF:21.464).

[2] Filby CE, Williamson R, van Kooy P, et al. Stimulation of Activin A/Nodal signaling isinsufficient to induce definitive endoderm formation of cord blood-derivedunrestricted somatic stem cells. Stem Cell Res Ther. 2011 Apr 4;2(2):16. doi: 10.1186/scrt57(IF:4.627).

冰袋运输，-25~-15℃保存，有效期2年。