[ 1 ]Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins

[ 2 ]A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin

[ 3 ]De novo design of GPCR exoframe modulators

[ 4 ]STING–NF-κB signaling builds an influenza spillover barrier

[ 5 ]Stabilizing MARCH7 as a ferro-guardian against ferroptosis

[ 6 ]Rational design of Gi-biased CB1 agonist with reduced side effects

[ 7 ]AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

[ 8 ]LncRNA NEAT1 promotes immunosuppression in gastric cancer under endoplasmic reticulum stress by maintaining the M6A methylation of SEMA3A in CAFs

[ 9 ]SCGN deficiency is a risk factor for autism spectrum disorder

[ 10 ]TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion

[ 11 ]Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease

[ 12 ]NirFAP680: a highly bright and stable large Stokes shift near-infrared fluorogen-activating protein

[ 13 ]CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer

[ 14 ]Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

[ 15 ]A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency

[ 16 ]An SLCO2B1 mRNA Isoform Acts as a Noncoding RNA to Drive Cancer Progression by Triggering Protein Biosynthesis

[ 17 ]Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma

[ 18 ]CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy

[ 19 ]FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival

[ 20 ]ORF8 protein of SARS-CoV-2 reduces male fertility in mice

[ 21 ]SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function

[ 22 ]Recoding multiple rare codons enables the simultaneous incorporation of up to five distinct noncanonical amino acids

[ 23 ]High-fat diet exacerbates experimental colitis by inhibiting lysosomal function via the STAT3-TFEB Axis

[ 24 ]ANXA11 suppression restores muscular function in the mdx mouse model of Duchenne muscular dystrophy (DMD)

[ 25 ]An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression

[ 26 ]Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation

[ 27 ]Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2

[ 28 ]Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer

[ 29 ]Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

[ 30 ]Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion

[ 31 ]Inhibition of base editors with anti-deaminases derived from viruses

[ 32 ]Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor

[ 33 ]Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma

[ 34 ]circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation

[ 35 ]circTNIK Promotes Carbon Nanotubes-Induced Lung Carcinogenesis via GRP78-Mediated Endoplasmic Reticulum Stress and Suppression of Type I Interferon Signaling

[ 36 ]UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model

[ 37 ]UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis

[ 38 ]Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency

[ 39 ]Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network

[ 40 ]OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation

[ 41 ]The RNA-binding protein hnRNP F is required for the germinal center B cell response

[ 42 ]Recognition of an Ala-rich C-degron by the E3 ligase Pirh2

[ 43 ]Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction

[ 44 ]Advanced glycation end-products exacerbate myocardial ischemia/reperfusion injury by promoting mitochondrial oxidative damage and PANoptosis in diabetes mellitus

[ 45 ]Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress

[ 46 ]Live-cell imaging of RNA dynamics using bright and stable fluorescent RNAs

[ 47 ]Structural Basis for the Action Mechanism of Legionella Glycosyltransferase

[ 48 ]Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription

[ 49 ]An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments

[ 50 ]FSHR and LHR functional compensation reveals the mechanism and treatment of Ovarian Hyperstimulation Syndrome

[ 51 ]CircRNA inhibits DNA damage repair by interacting with host gene

[ 52 ]Structure-based investigation of fluorogenic Pepper aptamer

[ 53 ]ATM promotes PFKP nuclear translocation to balance glycolysis and homologous recombination repair

[ 54 ]Regulated transformation system (RTS): sddi-mediated programmable shut-off and mode switching of base editors

[ 55 ]KIF2A-mediated microtubule-dependent nuclear envelope invagination drives nonhomologous end joining

[ 56 ]Development and application of G4-Flame as a visual biosensor for G4-DNA

[ 57 ]A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

[ 58 ]NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma

[ 59 ]Engineered Dll4-overexpressing osteocyte-derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis

[ 60 ]Cytoplasmic relocation of nuclear Ku70 by Bruceine A augments cGAS–STING pathway-mediated anti-tumor immunity

[ 61 ]Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis

[ 62 ]Targeting eIF5A combats breast cancer progression by ClpP-dependent mitochondrial oxidative stress

[ 63 ]Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

[ 64 ]BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

[ 65 ]Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

[ 66 ]Machine Learning-Guided Engineering of Protein Phase Separation Properties in Immune Regulation

[ 67 ]Covalent capture and genetic code expansion enables chemoproteomic profiling and functional characterization of lysine acetoacetylation

[ 68 ]Genome-wide association study reveals genetic architecture and evolution of human retinal pigmentation

[ 69 ]Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling

[ 70 ]RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1

[ 71 ]Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-β axis

[ 72 ]Vacuolization in Cytoplasm and Cell Membrane Permeability Enhancement Triggered by Micrometer-Sized Graphene Oxide

[ 73 ]A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing

[ 74 ]Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1

[ 75 ]AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

[ 76 ]Targeted Inhibition of P. gingivalis OMV-derived TsRNA by tetrahedral framework nucleic acids promotes periodontal regeneration

[ 77 ]Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors

[ 78 ]A dual-regulation inducible switch system for microRNA detection and cell type-specific gene activation

[ 79 ]Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells

[ 80 ]Mitochondrial DNA release via VDAC1 in keratinocytes: a key driver of innate immunity and vitiligo pathogenesis

[ 81 ]ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

[ 82 ]Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

[ 83 ]Unveiling a novel function of Aconitase-2: attenuating lung ischemia-reperfusion injury via inhibition of pulmonary endothelial apoptosis

[ 84 ]p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer

[ 85 ]Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

[ 86 ]Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication

[ 87 ]MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism

[ 88 ]Targeting c-Myc-p300-CARM1 complex induces ferroptosis and reduces CD8+ T cell exhaustion in esophageal squamous cell carcinoma

[ 89 ]KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

[ 90 ]Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma

[ 91 ]Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9

[ 92 ]Cas12a variants designed for lower genome-wide off-target effect through stringent PAM recognition

[ 93 ]A Universal Chemoenzymatic Labeling System for Profiling Cell-Cell Interactions and Potentiating Targeted Tumor Immunotherapy

[ 94 ]LncRNA Gm16023 ameliorates hyperglycemia-exacerbated septic intestinal injury by modulating macrophage polarization via miR-377-3p/Sirt1 axis

[ 95 ]UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

[ 96 ]Aloesin improves metabolic associated fatty liver disease and obesity by targeting TGFBR1

[ 97 ]Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway

[ 98 ]Ganoderic acid D alleviates vascular aging by restoring lysosomal function via stabilization of the VAPB–SNX25 tethering complex

[ 99 ]Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1

[ 100 ]SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network