Photo-controlled degradation of PLGA/Ti3C2 hybrid coating on Mg-Sr alloy using near infrared light
Li Liu, Bo Huang, Xiangmei Liu, Wei Yuan, Yufeng Zheng, Zhaoyang Li, Kelvin Wai Kwok Yeung, Shengli Zhu, Yanqin Liang, Zhenduo Cui, Shuilin Wu
Journal:Bioactive Materials
IF:8.72
DOI:10.1016/j.bioactmat.2020.08.013
PMID:32995680
Published:2020-09-15
research field:生物医学工程表面涂层技术材料科学
Abstract
A PLGA/Ti 3 C 2 hybrid coating was successfully deposited on the surface of magnesium-strontium (Mg-Sr) alloys. Compared with the corrosion current density ( i corr ) of the Mg-Sr alloy (7.13 × 10 −5 A/cm 2 ), the modified samples (Mg/PLGA/Ti 3 C 2 ) was lower by approximately four orders of magnitude (7.65 × 10 −9 A/cm 2 ). After near infrared 808 nm laser irradiation, the i corr of the modified samples increased to 3.48 × 10 −7 A/cm 2 . The mechanism is that the local hyperthermia induced the free volume expansion of PLGA, and the increase in intermolecular gap enhanced the penetration of electrolytes. Meanwhile, the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility.
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