MYSM1通过RSK3-BAD磷酸化通路诱导三阴性乳腺癌细胞凋亡并增强顺铂敏感性
MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3–phospho-BAD pathway
Guan Xiaolin, Meng Xin, Zhu Keyu, Kai Jinyan, Liu Yixuan, Ma Qian, Tong Ying, Zheng Hui, Xie Suhong, Ma Xiaolu, Wang Yanchun, Lu Renquan, Guo Lin
Journal：Cell Death Discovery
IF：7.11
DOI：10.1038/s41420-022-00881-1
PMID：35217648
Published：2022-02-26
research field：肿瘤学细胞生物学
Abstract
Breast cancer is one of the leading causes of mortality among women. Triple-negative breast cancer (TNBC) is responsible for a large percentage of all breast cancer deaths in women. This study demonstrated the function of Myb-like, SWIRM, and MPN domains 1 (MYSM1), an H2A deubiquitinase (DUB), in TNBC. MYSM1 expression was drastically decreased in breast cancer, especially in TNBC, suggesting a potential anticancer effect. Overexpressing and suppressing MYSM1 expression in TNBC cell lines led to significant biological changes in cell proliferation. Furthermore, MYSM1 overexpression increased cisplatin-induced apoptosis, which might be attributed to RSK3 inactivation and the subsequently decreased phosphorylation of Bcl-2 antagonist of cell death (BAD) (Ser 112). The findings suggest that MYSM1 is a potential target for regulating cell apoptosis and suppressing resistance to cisplatin in TNBC.
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