Sotorasib，又称索托拉西布，是可口服的KRAS G12C共价抑制剂，抑制SOS1催化的重组突变体KRAS (G12C/C118A)的核苷酸交换，将KRAS G12C锁定在非活跃的GDP约束状态，具有潜在的抗肿瘤活性。

参考文献

[1] Anne Y. Saiki, Kevin Gaida, Karen Rex, et al. Abstract 4484: Discovery and in vitro characterization of AMG 510–a potent and selective covalent small-molecule inhibitor of KRAS^G12C. Cancer Res (2019) 79 (13_Supplement): 4484. https://doi.org/10.1158/1538-7445.AM2019-4484.

[2] Canon J, Rex K, Saiki AY, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1(43.07).

-25~-15℃保存，有效期3年。