10Panx是一种多肽类、竞争性的Pannexin 1(PANX1)通道选择性抑制剂。其通过抑制PANX1通道的开放,进而阻断ATP释放及其下游的P2X7受体信号通路,最终发挥减少细胞死亡和炎症反应的作用。基于此机制,10Panx在神经病理性疼痛、炎症性肠病及艰难梭菌感染等疾病模型中展现出治疗潜力,具体表现为有效缓解机械痛觉过敏、抑制C反射增强以及降低IL-6等促炎因子的表达。
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-85~-65℃避光保存,有效期2年。
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