Latrunculin A (LAT-A)具有有效的抗肿瘤转移特性和细胞迁移抑制功能。其作用机制是通过结合肌动蛋白单体(包括 ATP-actin 和 ADP-Pi-actin),抑制 G-肌动蛋白的聚合。该物质发现自红海海绵 Latrunculia magnifica。
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-25~-15℃保存,有效期2年。
[1] Doller A, Badawi A, Schmid T, Brauss T, Pleli T, zu Heringdorf DM, Piiper A, Pfeilschifter J, Eberhardt W. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res. 2015 Jan 1;330(1):66-80. doi: 10.1016/j.yexcr.2014.09.010. Epub 2014 Sep 21. PMID: 25240929.[2]Konishi H, Kikuchi S, Ochiai T, Ikoma H, Kubota T, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Sonoyama T, Kokuba Y, Sasaki H, Matsui T, Otsuji E. Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Res. 2009 Jun;29(6):2091-7. PMID: 19528469.





