Q：如果报告基因检测无明显活性，可能跟什么有关系？

A：首先需要确认检测试剂盒的检测性能，另外确认质粒测序的正确性，以及本身信号通路的激活

[1] Chen H, Moreno-Moral A, Pesce F, et al. WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling [published correction appears in Nat Commun. 2019 Sep 9;10(1):4085]. Nat Commun. 2019;10(1):3616. Published 2019 Aug 9. doi:10.1038/s41467-019-11551-9(IF:11.878)
[2] Sun Q, Xu Y, Yuan F, et al. Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma. Cell Biosci. 2022;12(1):53. Published 2022 May 3. doi:10.1186/s13578-022-00791-w(IF:7.133)
[3] Yuan F, Sun Q, Zhang S, et al. The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Cell Biosci. 2022;12(1):20. Published 2022 Feb 25. doi:10.1186/s13578-022-00764-z(IF:7.133)
[4] Gao L, Liu J, Xu P, et al. AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway. Front Pharmacol. 2020;11:1102. Published 2020 Jul 31. doi:10.3389/fphar.2020.01102(IF:4.225)
[5] Ma Y, Du X, Zhao D, et al. 18:0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice. Biochem Biophys Res Commun. 2021;579:168-174. doi:10.1016/j.bbrc.2021.09.059(IF:3.575)
[6] Ding X, Deng G, Liu J, et al. GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway. Brain Res. 2019;1717:117-126. doi:10.1016/j.brainres.2019.03.035(IF:2.929)