Enzalutamide又称为MDV3100、MDV-3100，是一种雄性激素受体(Androgen-Receptor, AR)拮抗剂，IC₅₀为36 nM，阻断雄性激素与AR结合，阻止核转位和配位受体复合物招募辅激活因子。Enzalutamide具有口服生物活性，诱导肿瘤细胞凋亡，并诱导小鼠肿瘤衰退，促进细胞自噬，是细胞自噬的激活剂。

参考文献

[1]. Guerrero J, et al. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. The Prostate, 73(12): 1291–1305 (2013).

[2]. Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 324(5928): 787-790 (2009). 

[3]. Scher HI, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 375(9724): 1437-1446 (2010).

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。