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CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity
CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity
Li Luying, Ding Peipei, Lv Xinyue, Xie Suhong, Li Ling, Chen Jianfeng, Zhou Danlei, Wang Xiaochao, Wang Qi, Zhang Wei, Xu Yanqing, Lu Renquan, Hu Weiguo
Journal：Cancer Immunology Research
IF：12.02
DOI：10.1158/2326-6066.CIR-21-1072
PMID：
Published：2022-12-02
research field：肿瘤学分子生物学细胞信号传导肿瘤免疫学癌症生物学免疫学
Abstract
The subcellular compartmentalization of Ras is regulated by interacting with intracellular CD59. CD59 deficiency results in reduced trafficking of Ras to the plasma membrane in T cells, thus inducing increased T-cell signal transduction and antitumor activity.
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