聚单宁酸纳米棒功能化多糖水凝胶用于糖尿病伤口愈合

Abstract

Polysaccharide hydrogel dressings are strong candidates for wound healing due to their low-cost, adsorbable, biodegradable, and biocompatible features. However, they may have some drawbacks, such as static properties, weak mechanics, and the inability to fully meet the requirements of the different phases of wound repair. Enhanced functionality achieved by incorporating nanomaterials into traditional polysaccharide networks is an effective way to address these challenges. Herein, an all-in-one hydrogel dressing (OQP2) that possessed hemostasis , antibacterial, reactive oxygen species scavenging, and angiogenic properties was readily synthesized by introducing poly(tannic acid) nanorods into a polysaccharide matrix comprising oxidized β-glucan and quaternary ammonium chitosan. As expected, the OQP2 can accelerate wound healing in diabetic rat models. This study offers a convenient and facile one-pot strategy to construct multifunctional polysaccharide hydrogel dressings for treating diabetic wounds.