IFN-τ is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN-τ has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/β. The current investigation concerns the effect of recombinant ovine IFN-tau (rOvIFN-τ) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN-τ was shown to down regulate IFN-γ-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in down regulating inflammation in the central nervous system (CNS). IFN-τ did not upregulate the expression of MHC class II on CVE. IFN-τ also inhibited the replication of Theilers virus in CVE.
高纯度、高活性、低内毒素、高批间一致性
-25 ~ -15℃保存,收到货之后有效期1年。 复溶后,无菌条件下,2~8℃保存,7天有效期。复溶后, 无菌条件下,-85 ~ -65℃保存,3个月有效期。
[91204ES]Recombinant Human IFN-gamma Protein, His tag 重组人干扰素-γ
[91218ES]Recombinant Equine IFN-γ 重组马干扰素-γ
[91215ES]Recombinant Canine IFN-γ 重组犬干扰素-γ
[91214ES]Recombinant Mouse IFN-λ3/IL-28B 重组小鼠白介素-28B
[91213ES]Recombinant Mouse IFN-λ2/IL-28A 重组小鼠白介素-28A
[91211ES]Recombinant Rhesus Macaque IFN-γ 重组恒河猴干扰素-γ
[91210ES]Recombinant Human IFN-α2c 重组人干扰素-α2c
[91216ES]Recombinant Rat IFN-gamma Protein 重组大鼠干扰素-γ
[91212ES]Recombinant Mouse IFN-gamma Protein 重组小鼠干扰素-γ