This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

推荐稀释比 WB:1/500-1/1000;FC:1/50-1/100;ELISA:1/10000

Western blot analysis of ZAP70 in MLOT4 (1) cell lysate using ZAP70 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。