Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
Shuqiang Chen, Guoqiang Dong, Shanchao Wu, Na Liu, Wannian Zhang, Chunquan Sheng
Journal：Acta Pharmaceutica Sinica B
IF：6.01
DOI：10.1016/j.apsb.2018.08.003
PMID：30766786
Published：2018-08-20
research field：肿瘤学药理学细胞生物学
Abstract
Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms.
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