[ 1 ]Chiral Au@Ag Nanoparticles Regulate Macrophage Reprogramming for Enhanced Anti-Tumor Efficacy

[ 2 ]High-fat diet exacerbates experimental colitis by inhibiting lysosomal function via the STAT3-TFEB Axis

[ 3 ]Ferritin-Based Mild Magnetic Hyperthermia Therapy for Bladder Cancer: A Synergistic Anti-Inflammatory Strategy

[ 4 ]Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress

[ 5 ]Engineering mitochondrial uncoupler synergistic photodynamic nanoplatform to harness immunostimulatory pro-death autophagy/mitophagy

[ 6 ]Synergistic Lysosomal Impairment and ER Stress Activation for Boosted Autophagy Dysfunction Based on Te Double-Headed Nano-Bullets

[ 7 ]KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses

[ 8 ]Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment

[ 9 ]Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

[ 10 ]Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

[ 11 ]A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production

[ 12 ]An ATP-Regulated Ion Transport Nanosystem for Homeostatic Perturbation Therapy and Sensitizing Photodynamic Therapy by Autophagy Inhibition of Tumors

[ 13 ]Lysosome-targeted degradation of leucine-rich alpha-2 glycoprotein 1 enables chemosensitization to 5-fluorouracil in colorectal cancer

[ 14 ]TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation

[ 15 ]Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

[ 16 ]Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications

[ 17 ]Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation

[ 18 ]Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

[ 19 ]Polystyrene Microplastics Disrupt the Blood-Testis Barrier via CEBPB-Driven Lysosomal Autophagy and Induce Ferroptosis-like Injury in Human Sperm, Compromising Embryo Development

[ 20 ]Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies

[ 21 ]Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells

[ 22 ]Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection

[ 23 ]Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis

[ 24 ]Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1

[ 25 ]PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment

[ 26 ]Semaglutide attenuates diabetic vascular calcification by enhancing autophagy and lysosomal function via targeting CPNE1

[ 27 ]Lipid metabolism and autophagy maintain cellular homeostasis under chloroplast dysfunction in Chlamydomonas reinhardtii

[ 28 ]FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

[ 29 ]Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance

[ 30 ]Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation

[ 31 ]Targeting fPRDM16 to Restore Collagen Phagocytosis: A Mechanism to Counteract the Persistent Fibrosis in Aging Lungs

[ 32 ]PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells

[ 33 ]Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor

[ 34 ]Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription

[ 35 ]Imidacloprid induces hepatocyte inflammation and pyroptosis in grass carp through AMPK-mediated mitophagy and lysosomal dysfunction: mechanism and the alleviating effect of quercetin

[ 36 ]PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming

[ 37 ]Escitalopram accelerated aging via impaired IIS/autophagy signaling pathway

[ 38 ]ZNRF2-mediated CD-M6PR degradation and lysosomal dysfunction aggravate cellular senescence and aging

[ 39 ]Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation

[ 40 ]DHA Protects Hepatocytes from Oxidative Injury through GPR120/ERK-Mediated Mitophagy

[ 41 ]Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma

[ 42 ]The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

[ 43 ]Mechanistic insights into dietary CuO nanoparticles (CuO NPs)-induced hepatic lipotoxicity: The critical role of the Ccs/Mek1/Erk1/2/Pparα pathway and mitochondrial oxidative stress

[ 44 ]Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function

[ 45 ]RIP1 Mediates Manzamine-A-Induced Secretory Autophagy in Breast Cancer

[ 46 ]Cepharanthine inhibits lysosomes and induces apoptosis in triple‑negative breast cancer cells

[ 47 ]Ginsenoside Rg5 inhibits colorectal cancer, at least partially by blocking the lysosomal degradation of colorectal cancer cells

[ 48 ]Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

[ 49 ]Selenium nanoparticles fabricated in laminarin polysaccharides solutions exert their cytotoxicities in HepG2 cells by inhibiting autophagy and promoting apoptosis

[ 50 ]Chemosensitivity enhanced by autophagy inhibition based on a polycationic nano-drug carrier

[ 51 ]Avian pathogenic Escherichia coli virulence protein Hcp2a induces incomplete autophagy in chicken HD11 cells

[ 52 ]An activatable liposomal fluorescence probe based on fluorescence resonance energy transfer and aggregation induced emission effect for sensitive tumor imaging

[ 53 ]Swainsonine-induced vacuolar degeneration is regulated by mTOR-mediated autophagy in HT22 cells

[ 54 ]Forkhead box protein A2 alleviates toll-like receptor 4-mediated inflammation, endoplasmic reticulum stress, autophagy, and apoptosis induced by lipopolysaccharide in bovine hepatocytes

[ 55 ]ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity

[ 56 ]Synthesis and mechanism of biological action of morpholinyl-bearing arylsquaramides as small-molecule lysosomal pH modulators

[ 57 ]Self-quenched liposomal probes for tumor imaging based on cellular on/off system

[ 58 ]Mitochondria and Lysosomes Participate in Vip3Aa-Induced Spodoptera frugiperda Sf9 Cell Apoptosis

[ 59 ]Ambroxol enhances anti-cancer effect of microtubule-stabilizing drug to lung carcinoma through blocking autophagic flux in lysosome-dependent way

[ 60 ]Palladium nanoparticles induce autophagy and autophagic flux blockade in Hela cells

[ 61 ]Graphene oxide aggravated dextran sulfate sodium-induced colitis through intestinal epithelial cells autophagy dysfunction