工程化诺氟沙星碳化聚合物点协同抗菌抗炎治疗牙周炎

Abstract

Oral microecological dysbiosis sustains the chronic inflammation characteristic of periodontitis. Although mechanical debridement with adjunctive antibiotics remains the clinical mainstay, fluoroquinolones often show limited site-specific efficacy because of poor aqueous solubility and low bioavailability. Drug-derived carbonized polymer dots (CPDs) have therefore attracted increasing interest for integrating intrinsic pharmacological activity with tunable functional properties. Here, we develop norfloxacin-derived CPDs (NF-CPDs) exhibiting excellent biocompatibility and markedly enhanced antibacterial performance relative to free norfloxacin in planktonic bacterial environments. NF-CPDs preserve the canonical quinolone antibacterial mechanism while establishing a three-dimensional, synergistic inhibition framework spanning metabolism, energy, and bacterial structure. In parallel, NF-CPDs efficiently scavenge reactive oxygen species (ROS), suppress pro-inflammatory mediator expression, and attenuate excessive nuclear factor κB (NF-κB) signaling. In vivo , NF-CPDs mitigate alveolar bone resorption and preserve periodontal structural integrity. Collectively, this core–shell NF-CPDs platform enables synergistic antibacterial and anti-inflammatory therapy, providing a promising strategy for comprehensive periodontitis treatment.