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分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
细胞因子
重组蛋白
抗体
高通量测序建库
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材

新型化合物0411通过上调DUSP5发挥抗乙肝病毒活性的机制研究

Antiviral activity of novel chemical compound 0411, derived from FUBP1-IN-1 against hepatitis B virus by upregulation of DUSP5

Shuang Zhao, Haisha Wei, Yi Liang, Hui Fan

Journal:BIOCHEMICAL PHARMACOLOGY

IF:6.5

DOI:10.1016/j.bcp.2026.117983

PMID:

Published:2026-04-16

research field:药物发现病毒学分子医学肝病学

Abstract

Current first-line drugs rarely achieve functional cures   for chronic hepatitis B patients, which urges us to explore novel anti-HBV therapeutic strategies. In this study, we found that the novel chemical compound 0411, a derivative of the FUBP1 inhibitor, FUBPI-IN-1, significantly suppressed HBV transcription both in vitro and in vivo. Transcriptome sequencing demonstrated that 0411 treatment markedly upregulated the expression of the dual-specificity phosphatase 5 (DUSP5) gene, a crucial regulator of the MAPK pathway. Further functional studies illustrated that the antiviral activity of compound 0411 was dependent on DUSP5. Mechanismly, 0411 treatment in HepG2-NTCP cells enhances the deposition of active histone modifications on the promoter of DUSP5 significantly. In conclusion, our findings demonstrate the potential of 0411 as an effective agent against HBV transcription.

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